24(S)-Hydroxycholesterol induces ER dysfunction-mediated unconventional cell death
نویسندگان
چکیده
منابع مشابه
Endogenous 24S-hydroxycholesterol modulates NMDAR-mediated function in hippocampal slices.
N-methyl-D-aspartate receptors (NMDARs), a major subtype of glutamate receptors mediating excitatory transmission throughout the central nervous system (CNS), play critical roles in governing brain function and cognition. Because NMDAR dysfunction contributes to the etiology of neurological and psychiatric disorders including stroke and schizophrenia, NMDAR modulators are potential drug candida...
متن کاملRunning head: Endogenous 24S-hydroxycholesterol modulates NMDARs
Mennerick 1, 2, 3 5 6 Author contributions: M-Y.S, Y.I., C.F.Z and S.J.M designed research and experiments; M-Y.S, 7 Y.I. and A.B. performed experiments and tissue collection for 24S-HC level measurement; M8 Y.S, Y.I., C.F.Z and S.J.M contributed to data interpretation and analysis; M-Y.S and S.J.M 9 drafted the manuscript with input from all authors. 10 11 Author affiliation: 1 Department of P...
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Lipid peroxidation products have been known to induce cellular adaptive responses and enhance tolerance against subsequent oxidative stress through up-regulation of antioxidant compounds and enzymes. 24S-hydroxycholesterol (24SOHC) which is endogenously produced oxysterol in the brain plays an important role in maintaining brain cholesterol homeostasis. In this study, we evaluated adaptive resp...
متن کامل24S-hydroxycholesterol and 25-hydroxycholesterol differentially impact hippocampal neuronal survival following oxygen-glucose deprivation
N-methyl-D-aspartate receptors (NMDARs), a major subtype of glutamate receptor mediating excitatory transmission throughout the CNS, participate in ischemia-induced neuronal death. Unfortunately, undesired side effects have limited the strategy of inhibiting/blocking NMDARs as therapy. Targeting endogenous positive allosteric modulators of NMDAR function may offer a strategy with fewer downside...
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Abstract: Coxsackievirus B3 (CVB3) is the most common agent known to cause viral myocarditis. The viral genome encodes a single polyprotein that is cleaved to produce several proteins by virally encoded proteases. Most of this proteolytic processing is catalyzed by a cysteine protease called 3C. The 3C protease plays major role in viral replication and cellular damage. To understand the mecha...
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ژورنال
عنوان ژورنال: Cell Death Discovery
سال: 2019
ISSN: 2058-7716
DOI: 10.1038/s41420-019-0192-4